Sodium Hydroxide → 1-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

HRID 545211Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 545211
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][N:11]=[C:12]2[CH:15]2[CH2:17][CH2:16]2)=[C:7]([O:18][CH3:19])[CH:6]=1)=[O:4].[OH-].[Na+]>C1COCC1.CO>[CH:15]1([C:12]2[C:13]3[C:8](=[C:7]([O:18][CH3:19])[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:14]=3)[CH:9]=[CH:10][N:11]=2)[CH2:16][CH2:17]1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 57440910Methyl 1-cyclopropyl-5-methoxyisoquinoline-7-carboxylate

Produkt 1

HCID 574408921-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

1-Cyclopropyl-5-methoxy-isoquinoline-7-carboxylic acid methyl ester (4.87 g, 18.9 mmol) was dissolved in THF (50 ml) and MeOH (50 ml), and 5N NaOH aq. (18.9 ml) was added thereto. After stirred at 60° C. for 2 h, the mixture was concentrated in vacuo. The residue was triturated with H2O and 5N HCl aq. (18.9 ml) and the insoluble solid was collected through filtration to obtain the intended compound as a colorless solid.

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue was triturated with H2O and 5N HCl aq. (18.9 ml)
  3. filtrationthe insoluble solid was collected through filtration

Quellen und Nachweise

ORD-Eintrag
ord-1e68417dd62749e19a7bc8698d5a89a8
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935712B2

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