Reaktionsgleichung
[CH2:1]([N:8]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCCC1.NN.[Ni]>[CH2:1]([N:8]1[CH:12]=[CH:11][C:10]([NH2:13])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Komponenten
5
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
To a solution containing 1-benzyl-3-nitro-1H-pyrazole (86 mg, 0.42 mmol) in tetrahydrofuran (2 mL), anhydrous hydrazine (100 μL) was added to the clear solution. Raney nickel (˜100 mg washed 3 times with 5 mL of anhydrous tetrahydrofuran) was then added in tetrahydrofuran (300 μL). Gas evolved from the mixture and the reaction was allowed to proceed for 5 min, after which time the raney nickel was removed by filtration through a celite plug. The solvent was removed in vacuo to afford 1-benzyl-1H-pyrazol-3-ylamine as a yellow oil, which was used in the following step with no further purification.
Aufarbeitung
- additionwas added to the clear solution
- customafter which time the raney nickel was removed by filtration through a celite plug
- customThe solvent was removed in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-247a4bc407534f37bbbd7bde30e7c7c2
- Quelldatensatz
- uspto-grants-2011_05
- Patentnummer
- US07935699B2
Verknüpfte Notizen
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