6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline → 3,4-Dihydro-6,7-dimethoxy-1-methylisoquinoline
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]([CH3:15])[NH:8][CH2:7][CH2:6]2.N1C=CC=CC=1.C(OC(=O)C)(=O)C>>[CH3:15][C:9]1[C:10]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:12]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:7][N:8]=1Komponenten
3
Versuchsvorschrift
6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, conversion>99%, ee 82% (GC, sample derivatised by treatment with acetic anhydride pyridine, Chirasil DEX CB, 25 m×0.25 mm, injector/detector 200° C., helium 20 psi, 170° C. for 20 minutes then ramp at 5° C./min to 200° C., hold for 10 minutes, retention times 30.18 minutes and 30.45 minutes).
Aufarbeitung
- customretention times 30.18 minutes and 30.45 minutes
Quellen und Nachweise
- ORD-Eintrag