Hydrochloric Acid → (4-Hydroxyphenoxy)acetic acid

HRID 546360

Reaktionsgleichung

Reaktionsgleichung von HRID 546360
C[O:2][C:3](=[O:13])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.Cl>[OH-].[Na+]>[OH:12][C:9]1[CH:8]=[CH:7][C:6]([O:5][CH2:4][C:3]([OH:13])=[O:2])=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 602731Methyl 2-(4-hydroxyphenoxy)acetate

Produkt 1

HCID 15881(4-Hydroxyphenoxy)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

(4-Hydroxy-phenoxy)-acetic acid methyl ester 11 (20 grams, 109.89 mmol) is added to 10% sodium hydroxide solution (100 mL) and heated to 90° C. on water bath for 6 hours. The reaction mixture is cooled to room temperature, and the pH is adjusted to 2 with distilled HCl. Crude 12, is filtered, dried, and can be recrystallised in appropriate solvent.

Aufarbeitung

  1. temperatureThe reaction mixture is cooled to room temperature
  2. filtrationCrude 12, is filtered
  3. customdried
  4. customcan be recrystallised in appropriate solvent

Quellen und Nachweise

ORD-Eintrag
ord-9b60dbd7e8564d3083558297cd3660ca
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935843B2

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