Hydrochloric Acid → (+/-)-trans-N-[(5-Chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine hydrochloride

HRID 546419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 546419
C(O)C.Cl.C(OC([NH:12][C@@H:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C@H:14]1[NH:19][C:20]([C:22]1[NH:23][C:24]2[C:29]([CH:30]=1)=[CH:28][C:27]([Cl:31])=[CH:26][CH:25]=2)=[O:21])=O)(C)(C)C>ClCCl>[ClH:31].[Cl:31][C:27]1[CH:28]=[C:29]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22]([C:20]([NH:19][C@@H:14]1[CH2:15][CH2:16][CH2:17][CH2:18][C@H:13]1[NH2:12])=[O:21])=[CH:30]2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68910309(+/-)-trans-N1-(tert-Butoxycarbonyl)-N2-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine

Produkt 1

HCID 18442870(+/-)-trans-N-[(5-Chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine hydrochlorideAusbeute 198,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A saturated ethanol solution (100 ml) of hydrochloric acid was added to a solution of (±)-trans-N1-(tert-butoxycarbonyl)-N2-[(5-chloroindol-2-yl)-carbonyl]-1,2-cyclohexanediamine (5.18 g) in dichloromethane (100 ml) at room temperature. After stirring for 2 days, the reaction mixture was concentrated under reduced pressure, diethyl ether (300 ml) was added to the resultant residue, and colorless precipitate formed was collected by filtration and dried to obtain the title compound (4.30 g) as a colorless solid.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated under reduced pressure, diethyl ether (300 ml)
  2. additionwas added to the resultant residue, and colorless precipitate
  3. customformed
  4. filtrationwas collected by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dee0fe48d2d44ef0bcf1a3d138aa8ceb
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935824B2

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