Ethyl Acetate → HCID 86628503, Verbindung

HRID 546664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 546664
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[F:23][C:24]1[CH:25]=[C:26]([C:30]2([CH2:55][OH:56])[CH2:35][CH2:34][CH2:33][N:32]3[N:36]=[C:37](/[CH:39]=[CH:40]/[C:41]4[CH:46]=[CH:45][C:44]([N:47]5[CH:51]=[C:50]([CH3:52])[N:49]=[CH:48]5)=[C:43]([O:53][CH3:54])[CH:42]=4)[N:38]=[C:31]23)[CH:27]=[CH:28][CH:29]=1.C(OCC)(=O)C.O.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[F:23][C:24]1[CH:25]=[C:26]([C:30]2([CH:55]=[O:56])[CH2:35][CH2:34][CH2:33][N:32]3[N:36]=[C:37](/[CH:39]=[CH:40]/[C:41]4[CH:46]=[CH:45][C:44]([N:47]5[CH:51]=[C:50]([CH3:52])[N:49]=[CH:48]5)=[C:43]([O:53][CH3:54])[CH:42]=4)[N:38]=[C:31]23)[CH:27]=[CH:28][CH:29]=1

Komponenten

6

Edukt 4

HCID 8857Ethyl AcetateHCID 159087TriacetoxyperiodinaneHCID 66839396(8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanolHCID 86585896Sodium bicarbonate water

Produkt 1

HCID 86628503HCID 86628503, VerbindungAusbeute 138,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Dess-Martin periodinane (304 mg) was added to a solution of (8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanol (165 mg) in methylene chloride (10 mL), and the reaction solution was stirred in a nitrogen atmosphere at room temperature for four hours. Ethyl acetate and saturated sodium bicarbonate water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 227 mg of the title compound. The property value of the compound is as follows.

Aufarbeitung

  1. customthe organic layer was separated
  2. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ae5115b819604094a7146598cc72f466
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935815B2

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