Hydrochloric Acid → 1-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

HRID 546668Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 546668
[ClH:1].[O:2]=[C:3]1[CH:8]([C:9]2[CH:14]=[C:13]([F:15])[C:12]([F:16])=[C:11]([F:17])[CH:10]=2)[CH2:7][CH2:6][CH2:5][N:4]1[NH:18]C(=O)OC(C)(C)C>C(OCC)(=O)C.C(Cl)(Cl)Cl>[ClH:1].[NH2:18][N:4]1[CH2:5][CH2:6][CH2:7][CH:8]([C:9]2[CH:10]=[C:11]([F:17])[C:12]([F:16])=[C:13]([F:15])[CH:14]=2)[C:3]1=[O:2]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 86628505Tert-butyl[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate

Produkt 1

HCID 668393791-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 4 N hydrochloric acid in ethyl acetate (1 mL) was added to a solution of tert-butyl [2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate (134 mg) in chloroform (1 mL), and the reaction solution was stirred at room temperature for three hours. The reaction solution was concentrated under reduced pressure to obtain 109 mg of the title compound. The property value of the compound is as follows.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e35641c369a24c5199398012af84500c
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935815B2

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