4-Fluoro-3-methylphenylacetonitrile → 2-(4-Fluoro-3-methylphenyl)acetamide

HRID 546774Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 546774
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][C:3]=1[CH3:11].C[Si](C)(C)[O:14][K].O.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH2:10])=[O:14])=[CH:4][C:3]=1[CH3:11]

Komponenten

5

Edukt 3

HCID 201118384-Fluoro-3-methylphenylacetonitrileHCID 86585896Sodium bicarbonate waterHCID 178504318HCID 178504318, Verbindung

Produkt 1

HCID 668394032-(4-Fluoro-3-methylphenyl)acetamideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

4-Fluoro-3-methylphenylacetonitrile (1.1 g) was dissolved in toluene (35 ml), and trimethylsiloxypotassium (3.7 g) was added. After stirring at 110° C. for 2.5 hours, saturated sodium bicarbonate water was added, followed by separation with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to obtain 863 mg of the title compound. The property values of the compound are as follows.

Aufarbeitung

  1. customfollowed by separation with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-11ced35569554d9dae2da493e6af642b
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935815B2

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