1-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole → 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide

HRID 54697

Reaktionsgleichung

Reaktionsgleichung von HRID 54697
[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[N:3]=1.[Br:19][C:20]1[S:24][C:23]([C:25](=[O:28])[CH2:26]Br)=[CH:22][CH:21]=1>CC(C)=O>[BrH:19].[NH2:1][CH:2]1[N:6]([CH2:7][CH2:8][N:9]2[CH2:10][CH2:11][O:12][CH2:13][CH2:14]2)[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[N:3]1[CH2:26][C:25](=[O:28])[C:23]1[S:24][C:20]([Br:19])=[CH:21][CH:22]=1

Komponenten

4

Edukt 2

HCID 5680111-(2-Morpholin-4-ylethyl)-2-aminobenzimidazoleHCID 19883982-Bromo-1-(5-bromothiophen-2-yl)ethan-1-one

Produkt 1

HCID 190408802-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromideAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Dissolve 2.46 g (10 mmol) of 2-amino-1-(2-morpholinoethyl)benzimidazole in 120 ml of acetone with heating. Subsequently, add 5-bromo-2-bromoacetylthiophene. After stirring, leave at room temperature for 3 to 4 hours. The 2-amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide precipitate is filtered, washed twice with 20 ml of acetone each time and with ether (20 ml) to obtain 4.7 g of the title compound.

Aufarbeitung

  1. temperaturewith heating
  2. customleave at room temperature for 3 to 4 hours
  3. filtrationThe 2-amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide precipitate is filtered
  4. washwashed twice with 20 ml of acetone each time

Quellen und Nachweise

ORD-Eintrag
ord-983dc768e9024bf4b4b1a009d593d4a6
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05623073

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