p-Chlorophenacyl bromide → 2-Amino-4-(4-chlorophenacyl)-1-(2-morpholinoethyl)benzimidazolium bromide

HRID 54701

Reaktionsgleichung

Reaktionsgleichung von HRID 54701
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6](=[O:9])[CH2:7][Br:8])=[CH:4][CH:3]=1.[NH2:12][C:13]1[N:17]([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:16]2[CH:26]=[CH:27][CH:28]=[CH:29][C:15]=2[N:14]=1>CC(C)=O>[Br-:8].[NH2:12][C:13]1[NH:14][C:15]2[C:29]([CH2:7][C:6]([C:5]3[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)=[O:9])=[CH:28][CH:27]=[CH:26][C:16]=2[N+:17]=1[CH2:18][CH2:19][N:20]1[CH2:21][CH2:22][O:23][CH2:24][CH2:25]1

Komponenten

4

Edukt 2

HCID 68303p-Chlorophenacyl bromideHCID 5680111-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole

Produkt 1

HCID 677118142-Amino-4-(4-chlorophenacyl)-1-(2-morpholinoethyl)benzimidazolium bromideAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

A solution of 2.33 g (10 mmol) of 4-chlorophenacyl bromide in 25 ml of acetone is added to a hot solution of 2-amino-1-(2-morpholinoethyl)benzimidazole (2.46 g, 10 mmol) in 75 ml of acetone. The mixture is stirred, heated at the boil for 5 minutes and maintained at room temperature. Three hours later a precipitate of the title compound appears, which is filtered and washed with acetone and with ether.

Aufarbeitung

  1. temperatureheated at the boil for 5 minutes
  2. customThree hours

Quellen und Nachweise

ORD-Eintrag
ord-aaf1ce63975b4e8fb7fd87ea52561c4b
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05623073

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