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Sodium Hydroxide → (4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methyl-phenyl]-propyl}-6-hydroxy-5-methoxy-biphenyl-3-yl)-acetic Acid

HRID 547142
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 547142
[OH-].[Na+].C[O:4][C:5](=[O:42])[CH2:6][C:7]1[CH:8]=[C:9]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([CH2:40][CH3:41])([C:25]3[CH:30]=[CH:29][C:28](/[CH:31]=[CH:32]/[C:33]([CH2:37][CH3:38])([OH:36])[CH2:34][CH3:35])=[C:27]([CH3:39])[CH:26]=3)[CH2:23][CH3:24])=[CH:18][CH:17]=2)[C:10]([OH:15])=[C:11]([O:13][CH3:14])[CH:12]=1.[Cl-].[NH4+]>CO.O1CCCC1>[CH2:23]([C:22]([C:19]1[CH:18]=[CH:17][C:16]([C:9]2[C:10]([OH:15])=[C:11]([O:13][CH3:14])[CH:12]=[C:7]([CH2:6][C:5]([OH:42])=[O:4])[CH:8]=2)=[CH:21][CH:20]=1)([C:25]1[CH:30]=[CH:29][C:28](/[CH:31]=[CH:32]/[C:33]([CH2:34][CH3:35])([OH:36])[CH2:37][CH3:38])=[C:27]([CH3:39])[CH:26]=1)[CH2:40][CH3:41])[CH3:24]
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Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 57708998(4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methyl-phenyl]-propyl}-6-hydroxy-5-methoxy-biphenyl-3-yl)-acetic acid methyl ester

Produkt 1

HCID 57708922(4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methyl-phenyl]-propyl}-6-hydroxy-5-methoxy-biphenyl-3-yl)-acetic AcidAusbeute 6 %

Reagenzien, Katalysatoren, Lösungsmittel

1
HCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

A 1 N sodium hydroxide aqueous solution (0.203 mL, 0.203 mmol) was added to a solution of (4′-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methyl-phenyl]-propyl}-6-hydroxy-5-methoxy-biphenyl-3-yl)-acetic acid methyl ester (Example 178-(3); 22.1 mg, 0.041 mmol) in methanol-tetrahydrofuran (1:1, 4 mL), and the mixture was stirred at room temperature overnight. The reaction mixture was then poured into a saturated aqueous ammonium chloride solution, followed by extraction with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (chloroform:methanol=10:1) to give the target compound as a colorless oil (1.3 mg, 6%).

Aufarbeitung

  1. extractionfollowed by extraction with dichloromethane
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting residue was purified by silica gel chromatography (chloroform:methanol=10:1)

Quellen und Nachweise

ORD-Eintrag
ord-04b52b706e0841859c7ce6fa322fbcc5
Quelldatensatz
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07935688B2

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