Ethylene Glycol → 2-(2-Bromo-5-fluorophenyl)-1,3-dioxolane

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 2.0 g (9.9 mmol) 2-bromo-5-fluorobenzaldehyde in 20 ml toluene were added 0.722 ml (13.0 mmol) ethane-1,2-diol and 5 mg (0.03 mmol) toluene-4-sulfonic acid monohydrate. The reaction mixture was heated in a rotary evaporator at 60° C. and 200 mbar during 4 h. After evaporation of the solvent and flash chromatography 2.32 g (95%) of the title compound were obtained as a colorless liquid.

Herkunft & Nachweise