Hydrochloric Acid → N-[6-Methyl-5-(piperidin-4-ylamino)-pyridin-2-yl]-acetamide dihydrochloride

HRID 547903

Reaktionsgleichung

Reaktionsgleichung von HRID 547903
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:16]([CH3:25])=[N:17][C:18]([NH:21][C:22](=[O:24])[CH3:23])=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[CH3:25][C:16]1[N:17]=[C:18]([NH:21][C:22](=[O:24])[CH3:23])[CH:19]=[CH:20][C:15]=1[NH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 671946624-(6-Acetylamino-2-methyl-pyridin-3-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 67196741N-[6-Methyl-5-(piperidin-4-ylamino)-pyridin-2-yl]-acetamide dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

A solution of 4-(6-acetylamino-2-methyl-pyridin-3-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.38 g, 1.09 mmol) in dioxane (10 mL) and 4 M HCl in dioxane (10 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 249.3 [M+H]+.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-7b29df6c0ea24dfd862028278f03c28b
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07939661B2

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