5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride → 5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

HRID 5481

Reaktionsgleichung

Reaktionsgleichung von HRID 5481
Cl.Cl.[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl>[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1

Komponenten

3

Edukt 1

HCID 233628335-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride

Produkt 1

HCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridineAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

After a suspension of 5-[2-(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride (13.31 g, 50 mmloes) in chloroform (200 ml) was washed with 3N sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, the combined chloroform layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

Aufarbeitung

  1. washwas washed with 3N sodium hydroxide (50 ml)
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialthe combined chloroform layer was dried over anhydrous magnesium sulfate
  4. distillationThen, the solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-d247e64e0eef42c0ae0a6b34795adbf6
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05244908

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