1-(2-Bromoethyl)-3-chlorobenzene → 1-(3-chlorophenethyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(2-Bromoethyl)-3-chlorobenzene	HCID 140140	—
Edukt	3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione	HCID 57422424	—
Produkt	1-(3-chlorophenethyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione	HCID 57944950	27%

Reaktionsschritte

Prepared as in example 10-52 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 3-chlorophenethyl bromide. Yield: 27%. MS M+H calculated 414.13; found 414.2. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.20 μM.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07939671B2
Quelldatensatz	uspto-grants-2011_05
ORD ID	ord-4aa5067da4cd40b288fb74e9b8e6137b
Quellennotiz	uspto-grants-2011_05