Water → 7,8-difluoro-4-methyl-3,4-dihydro-1,4-benzoxazepin-5(2H)-one

Beteiligte Stoffe

Reaktionsschritte

Sodium hydride (52 mg, 1.29 mmol) was added portionwise to a solution of 2,4,5-trifluoro-N-(2-hydroxyethyl)-N-methylbenzamide (300 mg, 1.29 mmol) in DMF (13 mL) and reaction was allowed to stir at RT for 2 hours. Water (30 mL) was added and the white solution was extracted with ethyl acetate (3×30 mL) and dried (MgSO4), filtered and evaporated to give the desired compound as a colourless oil (275 mg). The compound was used without further purification.

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