6-Chloro-3-methyl-(1,2,4)triazolo(4,3-b)pyridazine → 3-Methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine

HRID 548889

Reaktionsgleichung

Reaktionsgleichung von HRID 548889
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][OH:14].Cl[C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([CH3:25])=[N:23][N:24]=2)[N:21]=1>>[CH3:25][C:22]1[N:20]2[N:21]=[C:16]([O:14][CH2:13][C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)=[N:5][O:6][C:2]=3[CH3:1])[CH:17]=[CH:18][C:19]2=[N:24][N:23]=1

Komponenten

3

Edukt 2

HCID 9113876-Chloro-3-methyl-(1,2,4)triazolo(4,3-b)pyridazineHCID 2776149(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol

Produkt 1

HCID 671578353-Methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazineAusbeute 41 %

Versuchsvorschrift

As described for example 86, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (100 mg, 0.53 mmol) was converted, using 6-chloro-3-methyl-1,2,4-triazolo[4,3-b]pyridazine instead of 6-chloro-1,2,4-triazolo[4,3-b]pyridazine, to the title compound (70 mg, 41%) which was obtained as a white solid. MS: m/e=322.3 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-4bef297f7d074a0a88eafa1708dfd161
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07943619B2

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