Thionyl Chloride → (6-Chloro(3-pyridyl)methyl] (2-chloroethylamino}ethanenitrile

HRID 549223Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 549223
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:12][CH2:13][CH2:14]O)[C:10]#[N:11])=[CH:4][CH:3]=1.S(Cl)([Cl:18])=O>N1C=CC=CC=1.C(Cl)(Cl)Cl>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:12][CH2:13][CH2:14][Cl:18])[C:10]#[N:11])=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 24386Thionyl ChlorideHCID 86624867(6-Chloro(3-pyridyl)methyl](2-hydroxyethylamino}ethanenitrile

Produkt 1

HCID 86624866(6-Chloro(3-pyridyl)methyl] (2-chloroethylamino}ethanenitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

This compound was prepared in a manner analogous to that set forth in Step C of Example 1, using 5.7 grams (0.0255 mole) of 2-{[(6-chloro(3-pyridyl)methyl](2-hydroxyethylamino}ethanenitrile 3.2 grams (0.0268 mole) of thionyl chloride and one drop (catalyst) of pyridine in 50 mL of chloroform. The yield of the subject compound was 6.0 grams. The NMR spectrum was consistent with the proposed structure.

Aufarbeitung

  1. customThis compound was prepared in a manner analogous to that set forth in Step C of Example 1

Quellen und Nachweise

ORD-Eintrag
ord-58378f85ee644cb2850e5714cffc67a6
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07943642B2

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