Dimethylamine → N,N-Dimethyl-3-nitro-1H-pyrrol-2-amine

HRID 549228Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 549228
Cl[C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-:9])=[O:8].[CH3:10][NH:11][CH3:12]>>[CH3:10][N:11]([CH3:12])[C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-:9])=[O:8]

Komponenten

3

Edukt 2

HCID 674DimethylamineHCID 553005692-chloro-3-nitro-1H-pyrrole

Produkt 1

HCID 45121913N,N-Dimethyl-3-nitro-1H-pyrrol-2-amine

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

This compound was prepared in a manner analogous to that set forth in Step C of Example 2, using 0.65 gram (0.0045 mole) of 2-chloro-3-nitropyrrole (prepared in Steps D-F of Example 1) and 5.0 mL (excess) of dimethylamine. The microwave chemical reactor was maintained at 100° C. during a 45-minute period, after which time the reaction was considered to be complete. The crude product was purified with column chromatography on silica gel. Elution was accomplished using 25% hexane in diethyl ether, then 100% diethyl ether as eluants. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.2 gram of the subject compound. The NMR spectrum was consistent with the proposed structure.

Aufarbeitung

  1. customThis compound was prepared in a manner analogous to that set forth in Step C of Example 2
  2. customThe crude product was purified with column chromatography on silica gel
  3. washElution
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a8e431aa4fb14b27bcb644c66a0a0bbe
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07943642B2

Notizen zur Reaktion

Wird geladen…