Trifluoroacetic acid → (RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine

HRID 549318

Reaktionsgleichung

Reaktionsgleichung von HRID 549318
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:16][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:18][N:19]=1)=O)(C)(C)C.FC(F)(F)C(O)=O.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[C:20]1([C:17]2[O:16][C:15]([CH2:14][CH:9]3[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]3)=[N:19][N:18]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 11430Potassium CarbonateHCID 86628996(RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine-1-carboxylic acid tert butyl ester

Produkt 1

HCID 67157689(RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidineAusbeute 92,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of (RS)-2-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine-1-carboxylic acid tert butyl ester (0.175 g) in dichloromethane (4 ml) was cooled (ice bath) and treated with trifluoroacetic acid (1 ml). The mixture was stirred for 1 h, added to saturated potassium carbonate and the product extracted into dichloromethane. The organic phase was dried (MgSO4) and solvent removed at reduced pressure to give the title compound (0.115 g)

Aufarbeitung

  1. extractionthe product extracted into dichloromethane
  2. dry with materialThe organic phase was dried (MgSO4) and solvent
  3. customremoved at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-87e2773e6e7042bfb799c4cc0a702471
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07943645B2

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