Trifluoroacetic acid → HCID 178477906, Verbindung

HRID 549927Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 549927
C(O)(C(F)(F)F)=O.[Cl:8][C:9]1[CH:30]=[CH:29][C:12]2[NH:13][C:14]([N:16]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)=[N:15][C:11]=2[CH:10]=1>C(Cl)Cl>[Cl:8][C:9]1[CH:30]=[CH:29][C:12]2[NH:13][C:14]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[N:15][C:11]=2[CH:10]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 178452256HCID 178452256, Verbindung

Produkt 1

HCID 178477906HCID 178477906, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

TFA (2 mL) was added to a solution of tert-butyl 4-(5-chloro-1H-benzimidazol-2-yl)piperazine-1-carboxylate (72 mg) in DCM (2 mL) and the reaction was stirred for 1 h. The solvent was then evaporated under high vacuum for 1 h to afford the title compound as a gum which was used without further analysis.

Aufarbeitung

  1. customThe solvent was then evaporated under high vacuum for 1 h

Quellen und Nachweise

ORD-Eintrag
ord-35bbc3851f544ae092e4cdeb7b05263c
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07943768B2

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