2,4-Dichloro-6,7-dimethoxyquinazoline → 3-[1-(2-Chloro-6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1-ethyl-1,2,3,4-tetrahydro-6-nitro-2,4-dioxoquinazoline

HRID 55029

Reaktionsgleichung

Reaktionsgleichung von HRID 55029
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([N:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([N+:23]([O-:25])=[O:24])[CH:19]=3)[N:14]([CH2:26][CH3:27])[C:13]2=[O:28])[CH2:8][CH2:7]1)=O)C.Br.C(N1C2C(=CC([N+]([O-])=O)=CC=2)C(=O)N(C2CCNCC2)C1=O)C.[Cl:53][C:54]1[N:63]=[C:62](Cl)[C:61]2[C:56](=[CH:57][C:58]([O:67][CH3:68])=[C:59]([O:65][CH3:66])[CH:60]=2)[N:55]=1>>[Cl:53][C:54]1[N:63]=[C:62]([N:6]2[CH2:11][CH2:10][CH:9]([N:12]3[C:21](=[O:22])[C:20]4[C:15](=[CH:16][CH:17]=[C:18]([N+:23]([O-:25])=[O:24])[CH:19]=4)[N:14]([CH2:26][CH3:27])[C:13]3=[O:28])[CH2:8][CH2:7]2)[C:61]2[C:56](=[CH:57][C:58]([O:67][CH3:68])=[C:59]([O:65][CH3:66])[CH:60]=2)[N:55]=1

Komponenten

4

Edukt 3

HCID 5203272,4-Dichloro-6,7-dimethoxyquinazolineHCID 229234231-Ethyl-1,2,3,4-tetrahydro-6-nitro-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromideHCID 229234713-(1-Ethoxycarbonyl-4-piperidinyl)-1-ethyl-1,2,3,4-tetrahydro-6-nitro-2,4-dioxoquinazoline2×

Produkt 1

HCID 229234343-[1-(2-Chloro-6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1-ethyl-1,2,3,4-tetrahydro-6-nitro-2,4-dioxoquinazolineAusbeute 78 %

Versuchsvorschrift

The procedure similar to that described in Example 15 was repeated, except that 3.62 g (9.4 mmol) of 3-(1-ethoxycarbonyl-4-piperidinyl)-1-ethyl-1,2,3,4-tetrahydro-6-nitro-2,4-dioxoquinazoline (Compound ii) was used in place of Compound a, whereby 3.20 g of crude 1-ethyl -1,2,3,4-tetrahydro-6-nitro-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromide (Compound jj) was obtained. The product (198.0 mg) was treated in the similar manner as in Example 40, except for the use of 2,4-dichloro-6,7-dimethoxy-quinazoline in place of 4-chloro-6,7-dimethoxy-quinazoline, to give 220.7 mg (yield: 78%) of Compound 79 as pale yellow crystals.

Aufarbeitung

  1. customwas obtained

Quellen und Nachweise

ORD-Eintrag
ord-36a9fd8353b0419e94fc11d1b35d6e04
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05624926

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