2,4-Dichloro-6,7-dimethoxyquinazoline → 3-[1-(2-Chloro-6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-quinazoline

HRID 55032

Reaktionsgleichung

Reaktionsgleichung von HRID 55032
Br.[CH3:2][N:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[C:6](=[O:14])[N:5]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[C:4]1=[O:21].[Cl:22][C:23]1[N:32]=[C:31](Cl)[C:30]2[C:25](=[CH:26][C:27]([O:36][CH3:37])=[C:28]([O:34][CH3:35])[CH:29]=2)[N:24]=1>>[Cl:22][C:23]1[N:32]=[C:31]([N:18]2[CH2:19][CH2:20][CH:15]([N:5]3[C:6](=[O:14])[C:7]4[C:12](=[CH:11][CH:10]=[C:9]([CH3:13])[CH:8]=4)[N:3]([CH3:2])[C:4]3=[O:21])[CH2:16][CH2:17]2)[C:30]2[C:25](=[CH:26][C:27]([O:36][CH3:37])=[C:28]([O:34][CH3:35])[CH:29]=2)[N:24]=1

Komponenten

3

Edukt 2

HCID 5203272,4-Dichloro-6,7-dimethoxyquinazolineHCID 218512221,2,3,4-Tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromide2×

Produkt 1

HCID 154345133-[1-(2-Chloro-6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-quinazolineAusbeute 48 %

Versuchsvorschrift

The procedure similar to that described in Example 40 was repeated, except that 354.0 mg (1.0 mmol) of 1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)-quinazoline hydrobromide (Compound v) obtained in Example 41 was used and 2,4-dichloro-6,7-dimethoxyquinazoline was used in place of 4-chloro-6,7-dimethoxyquinazoline. As a result, 239.2 mg (yield: 48%) of Compound 78 was obtained as white crystals.

Aufarbeitung

  1. customobtained in Example 41

Quellen und Nachweise

ORD-Eintrag
ord-771c5b53373c4c84bb41953e46ea8a9a
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05624926

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