7-(Benzyloxy)-4-chloro-6-methoxyquinazoline → 3-[1-(7-Benzyloxy-6-methoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazoline

HRID 55038Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 55038
Br.[CH3:2][N:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[C:6](=[O:14])[N:5]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[C:4]1=[O:21].[CH2:22]([O:29][C:30]1[CH:39]=[C:38]2[C:33]([C:34](Cl)=[N:35][CH:36]=[N:37]2)=[CH:32][C:31]=1[O:41][CH3:42])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([O:29][C:30]1[CH:39]=[C:38]2[C:33]([C:34]([N:18]3[CH2:19][CH2:20][CH:15]([N:5]4[C:6](=[O:14])[C:7]5[C:12](=[CH:11][CH:10]=[C:9]([CH3:13])[CH:8]=5)[N:3]([CH3:2])[C:4]4=[O:21])[CH2:16][CH2:17]3)=[N:35][CH:36]=[N:37]2)=[CH:32][C:31]=1[O:41][CH3:42])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Komponenten

3

Edukt 2

HCID 106619987-(Benzyloxy)-4-chloro-6-methoxyquinazolineHCID 218512221,2,3,4-Tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromide2×

Produkt 1

HCID 229234363-[1-(7-Benzyloxy-6-methoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazolineAusbeute 42 %

Versuchsvorschrift

The procedure similar to that described in Example 57 was repeated, except that 369.0 mg (1.05 mmol) of 1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)-quinazoline hydrobromide (Compound v) obtained in Example 41 was used and 7-benzyloxy-4-chloro-6-methoxyquinazoline was used in place of 4-chloro-6,7-dimethoxyquinazoline. As a result, 233.8 mg (yield: 42%) of Compound 87 was obtained as white crystals.

Aufarbeitung

  1. customobtained in Example 41

Quellen und Nachweise

ORD-Eintrag
ord-9de39fc1549d47039b22cbe18030dffd
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05624926

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