[F:1][C:2]([F:11])([CH2:7][CH2:8][CH:9]=[CH2:10])[C:3]([NH:5][NH2:6])=O.C([O-])([O-])=O.[K+].[K+].Cl.[CH3:19][NH:20][C:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=NC>CO>[F:1][C:2]([C:3]1[N:20]([CH3:19])[C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[N:6][N:5]=1)([F:11])[CH2:7][CH2:8][CH:9]=[CH2:10]To a solution of 2,2-difluoro-5-hexenohydrazide (275 mg) in MeOH (8 ml) were added K2CO3 (232 mg) and N,N′-dimethylbenzenecarboximidamide hydrochloride (309 mmol). The solution was heated at reflux for 3 days. Volatiles were evaporated in vacuo and the crude was purified by column chromatography (DCM:MeOH=95 to 5) to give 45 mg of the title compound. MS (m/z): 264[MH]+.
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