3-Chloroaniline → 6-Methyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (3-chloro-phenyl)-amide hydrochloride
Reaktionsgleichung
C(O[C:4]([C:6]1[C:11]([NH2:12])=[N:10][CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])C.Br[C:15]1[CH:16]=[N:17][CH:18]=[N:19][CH:20]=1.[Cl:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25]>>[ClH:21].[Cl:21][C:22]1[CH:23]=[C:24]([NH:25][C:4]([C:6]2[C:11]([NH:12][C:15]3[CH:16]=[N:17][CH:18]=[N:19][CH:20]=3)=[N:10][CH:9]=[C:8]([CH3:13])[N:7]=2)=[O:5])[CH:26]=[CH:27][CH:28]=1Komponenten
4
Versuchsvorschrift
The title compound, MS: m/e=341.2 (M+H+), was prepared in accordance with the general method of example 10 from 3-amino-6-methyl-pyrazine-2-carboxylic acid ethyl ester (Example C), 5-bromopyrimidine and 3-chloroaniline.