Potassium Iodide → HCID 59257866, Verbindung

HRID 551079

Reaktionsgleichung

Reaktionsgleichung von HRID 551079
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7][NH:8]2)([O-:3])=[O:2].C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+].Br[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]>CC(C)=O>[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7][N:8]2[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])([O-:3])=[O:2]

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 7748Ethyl bromoacetateHCID 10340Sodium CarbonateHCID 10243182methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate

Produkt 1

HCID 59257866HCID 59257866, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of (±)-methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)acetate from Step B (700 mg, 2.97 mmol), sodium carbonate (471 mg, 4.44 mmol), and potassium iodide (98 mg, 0.59 mmol) in acetone (15 mL) was added ethyl bromoacetate (9.9 mL, 88.9 mmol). The mixture was heated at reflux for 18 h, then cooled to ambient temperature and concentrated in vacuo. The residue was partitioned between H2O (15 mL) and EtOAc (2×40 mL) and the organic extracts were washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo to a volume of 50 mL. Hexane was added to the EtOAc solution and a precipitate formed. The desired crystals were collected by vacuum filtration to give the title compound. MS: m/z=323 (M+1).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 18 h
  3. concentrationconcentrated in vacuo
  4. customThe residue was partitioned between H2O (15 mL) and EtOAc (2×40 mL)
  5. washthe organic extracts were washed with brine
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo to a volume of 50 mL
  9. additionHexane was added to the EtOAc solution
  10. customa precipitate formed
  11. filtrationThe desired crystals were collected by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-e813476fa1df4e488706c7fa1b06cbaf
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07947677B2

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