HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 1-(4-Cyanobenzyl)imidazole-5-acetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Lithium Hydroxide | HCID 3939 | — |
| Edukt | [1-(4-Cyanobenzyl)-1H-imidazol-5-yl]acetic acid methyl ester | HCID 10634751 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 1-(4-Cyanobenzyl)imidazole-5-acetic acid | HCID 18433630 | — |
Reaktionsschritte
A solution of [1-(4-cyanobenzyl)-1H-imidazol-5-yl]acetic acid methyl ester (4.44 g, 17.4 mmol ) in THF (100 ml) and 1M lithium hydroxide (17.4 ml, 17.4 mmol) was stirred at RT for 18 hr. 1M HCl (17.4 ml) was added and the THF was removed by evaporation in vacuo. The aqueous solution was lyophilized to afford the title compound containing lithium chloride as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05624936 |
| Quelldatensatz | uspto-grants-1997_04 |
| ORD ID | ord-0f7073cb653a437b995b8905a7eedf4b |
| Quellennotiz | uspto-grants-1997_04 |