3-(Trifluoromethyl)phenol → 4-Methylmercapto-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

HRID 55130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 55130
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[H-].[Na+].Cl[C:15]1[CH:20]=[C:19]([S:21][CH3:22])[CH:18]=[C:17]([O:23][CH2:24][C:25]2[CH:29]=[CH:28][S:27][CH:26]=2)[N:16]=1>CN(C)C=O.[Cu]I>[CH3:22][S:21][C:19]1[CH:20]=[C:15]([O:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=2)[N:16]=[C:17]([O:23][CH2:24][C:25]2[CH:29]=[CH:28][S:27][CH:26]=2)[CH:18]=1

Komponenten

6

Edukt 3

HCID 73763-(Trifluoromethyl)phenolHCID 24758Sodium hydrideHCID 539581302-Chloro-4-methylmercapto-6-(3-thienylmethyloxy)pyridine

Produkt 1

HCID 544816314-Methylmercapto-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)KatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution containing meta-trifluoromethylphenol (1.60 g, 0.0024×4.1 mol), sodium hydride (0.29 g, (ca.60% in mineral oil), 0.0024×3.0 mol) and CuI (0.22 g, 0.0024×0.5 mol) in dimethylformamide, 2-chloro-4-methylmercapto-6-(3-thienylmethyloxy)pyridine (0.64 g, 0. 0024 mol) was added and the resultant solution was refluxed for about 6 hours.

Aufarbeitung

  1. additionwas added

Quellen und Nachweise

ORD-Eintrag
ord-f9a20e6ae4d141f68ece0b6e8353fb8d
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05624942

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