Sodium hydride → 2-Chloro-4-methylamino-6-(3-thienylmethyloxy)pyridine
Reaktionsgleichung
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][OH:7])=[CH:2]1.[H-].[Na+].[Cl:10][C:11]1[CH:16]=[C:15]([NH:17][CH3:18])[CH:14]=[C:13](Cl)[N:12]=1>O1CCCC1>[Cl:10][C:11]1[CH:16]=[C:15]([NH:17][CH3:18])[CH:14]=[C:13]([O:7][CH2:6][C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)[N:12]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 3-thiophenemethanol (1.42 g, 0.0113×1.1 mol) in 20 ml of dry tetrahydrofuran, sodium hydride (1.35 g (ca.60% in mineral oil), 0.0113×3.0 mol) was added. After the bubbling ceased, a solution of 2,6-dichloro-4-methylaminopyridine (2.0 g, 0.0113 mol) in 30 ml of dry tetrahydrofuran was added dropwise at room temperature.
Quellen und Nachweise
- ORD-Eintrag
- ord-ed7deb2ac47349c198c996cbb3ace623
- Quelldatensatz
- uspto-grants-1997_04
- Patentnummer
- US05624942
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