Hydrochloric Acid → 5-(2-Aminoethyl)-2-methoxyphenylamine

HRID 551603Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 551603
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13]C(=O)C)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl>>[NH2:13][CH2:12][CH2:11][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([NH2:2])[CH:4]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 45074592N-(3-Amino-4-methoxyphenethyl)acetamide hydrochloride

Produkt 1

HCID 233197675-(2-Aminoethyl)-2-methoxyphenylamineAusbeute 94 %

Versuchsvorschrift

N-[-2-(3-amino-4-methoxyphenyl)ethyl]acetamide hydrochloride, prepared as described in Example 8 (15 g) and 175 mL of 2N HCl were heated at reflux for 6 hours. The solvent was removed by rotary evaporation, and the residue was washed with ethanol. The resulting white precipitate was filtered off and dried in vacuum, yielding 13.7 g (94%) of 5-(2-aminoethyl)-2-methoxyphenylamine (AMMPA) dihydrochloride as white crystals. 1HNMR (DMSO-d6) spectrum was consistent with the desired product.

Aufarbeitung

  1. temperaturewere heated
  2. temperatureat reflux for 6 hours
  3. customThe solvent was removed by rotary evaporation
  4. washthe residue was washed with ethanol
  5. filtrationThe resulting white precipitate was filtered off
  6. customdried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2e7c11cc7b2848d7b50355063670ea45
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07947761B2

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