2-Thiophenesulfonyl chloride → Methyl (4-{[{4-[(4-butylphenyl)ethynyl]benzyl}(2-thienylsulfonyl)-amino]methyl}phenoxy)acetate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a cold solution (0° C.) of methyl {4-[({4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]-phenoxy}acetate (40 mg, 0.091 mmol) in anhydrous pyridine (2 ml) was added 2-thiophenesulfonyl chloride (Aldrich, 82 mg, 0.45 mmol) and the reaction mixture was stirred at 0° C. for 4 hrs and at rt for an additional 15 hours. The reaction mixture was diluted with an aqueous solution of HCl (1N) and extracted with DCM (3×). The combined organic layers were dried over Na2SO4 and the solvent was removed under reduced pressure to give 30 mg (56%) of the title compound as a yellow oil. HPLC, Rt: 5.9 un purity: 92.5%). 1H NMR (CDCl3) δ: 7.61 (dd, J=5.3, 1.5 Hz, 1H), 7.58 (dd, J=3.8, 1.5 Hz, 1H), 7.44 (d, J=8.3 Hz, 2H), 7.39 (d, J=7.9 Hz, 2H), 7.17 (d, J=8.3 Hz, 2H), 7.12 (dd, J=5.3, 3.8 Hz, 1H), 7.04 (m, 4H), 6.78 (d, J=8.7 Hz, 2H), 4.61 (s, 2H), 4.33 (s, 2H), 4.30 (s, 2H), 3.81 (s, 3H), 2.63 (t, J=7.7 Hz, 2H), 1.61 (m, 2H), 1.37 (m, 2H), 0.94 (t, J=7.2 Hz, 3H).

Herkunft & Nachweise