Reaktionsgleichung
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:35]=[CH:34][C:16]([CH2:17][N:18]([CH2:30][CH:31]3[CH2:33][CH2:32]3)[C:19]3[CH:20]=[CH:21][C:22]([F:29])=[C:23]([CH:28]=3)[C:24]([O:26]C)=[O:25])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].CO[2H]>>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[C:12][C:13]2[CH:35]=[CH:34][C:16]([CH2:17][N:18]([CH2:30][CH:31]3[CH2:32][CH2:33]3)[C:19]3[CH:20]=[CH:21][C:22]([F:29])=[C:23]([CH:28]=3)[C:24]([OH:26])=[O:25])=[CH:15][CH:14]=2)=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH3:4]Komponenten
3
Versuchsvorschrift
The title compound was prepared following procedure described in example 36, step c) from methyl 5-[{4-[(4-butylphenyl)ethynyl]benzyl}(cyclopropylmethyl)amino]-2-fluorobenzoate (200 mg; 0.43 mmol) and obtained quantitatively (200 mg) as a white powder. HPLC, Rt: 5.45 min (purity: 97.7%), LC/MS, M−(ESI): 454.1, 1H M (MeOD) δ: 7.24-7.42 (m, 5H), 7.22 (d, J=7.9 Hz, 2H), 7.15 (d, J=7.7 Hz, 2H), 7.01 (d, J=7.9 Hz, 2H), 4.64 (s, 2H), 3.36 (d, J=6.4 Hz, 2H), 2.59 (t, J=7.9 Hz, 2H), 1.57 (m, 2H), 1.34 (m, 2H), 1.21 (m, 1H), 0.91 (t, J=7.3 Hz, 3H), 0.50 (m, 2H), 0.21 (m, 2H).
Aufarbeitung
- customobtained quantitatively (200 mg) as a white powder
Quellen und Nachweise
- ORD-Eintrag
- ord-ca2e6e10bd8a45c59bae40627543119e
- Quelldatensatz
- uspto-grants-2011_05
- Patentnummer
- US07947851B2
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