O-Phenylenediamine → 2,3-Bis(4-fluorophenyl)quinoxaline

HRID 552033

Reaktionsgleichung

Reaktionsgleichung von HRID 552033
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=O)=O)=[CH:4][CH:3]=1.[C:19]1([NH2:26])[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH2:25]>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[N:26][C:19]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:25]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 7243O-PhenylenediamineHCID 1230724,4'-Difluorobenzil

Produkt 1

HCID 22600502,3-Bis(4-fluorophenyl)quinoxalineAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

First, 3.71 g of 4,4′-difluorobenzil and 1.71 g of o-phenylenediamine were stirred on heating in a solvent (200 mL of chloroform) for 6 hours. The reaction solution was cooled to a room temperature, washed with 1 mol/L hydrochloric acid and a saturated aqueous solution of sodium chloride, and dried with magnesium sulfate. The solvent was removed to obtain a ligand 2,3-bis(4-fluorophenyl)quinoxaline) (abbreviation: HFdpq) (pale yellow powder, yield: 99%). A synthetic scheme (b-1) of Step 1 is shown below.

Aufarbeitung

  1. washwashed with 1 mol/L hydrochloric acid
  2. dry with materiala saturated aqueous solution of sodium chloride, and dried with magnesium sulfate
  3. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-a6a7025a4de740b5a2402d12ee6b74f8
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951471B2

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