56222-10-7 → N-[(4-aminophenyl)methyl]acetamide

HRID 552121Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 552121
[N+:1]([C:4]1[CH:14]=[CH:13][C:7]([CH2:8][NH:9][C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C1COCC1.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][NH:9][C:10](=[O:12])[CH3:11])=[CH:13][CH:14]=1

Komponenten

5

Edukt 2

HCID 4178456222-10-7HCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 228286N-[(4-aminophenyl)methyl]acetamideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4.0 g (21 mmol, 1.0 eq.) of N-(4-nitrobenzyl)acetamide (I-21) in 100 mL of THF was added a catalytic amount of Raney Nickel. The mixture was stirred under 1 atm. of hydrogen at room temperature for 16 h. The mixture was filtered through Celite® and the pad was washed with 100 mL of THF. The solvent was removed in vacuo to provide 3.4 g (21 mmol, 100%) of N-(4-aminobenzyl)acetamide (I-22).

Aufarbeitung

  1. filtrationThe mixture was filtered through Celite®
  2. washthe pad was washed with 100 mL of THF
  3. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-146d079e255f45ee93e4a7ebdedac062
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951803B2

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