Ammonium Acetate → 4,6,6-trimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide

HRID 552190Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 552190
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH2:15])[CH:14]=1)[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1.[CH3:16][N:17]1[CH2:22][C:21]([CH3:24])([CH3:23])[O:20][CH2:19][CH:18]1[C:25](O)=[O:26].C([O-])(=O)C.[NH4+]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH:15][C:25]([CH:18]3[CH2:19][O:20][C:21]([CH3:23])([CH3:24])[CH2:22][N:17]3[CH3:16])=[O:26])[CH:14]=1)[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1

Komponenten

4

Edukt 3

HCID 517165Ammonium AcetateHCID 213627016-Chloro-9H-beta-carbolin-8-amineHCID 671654624,6,6-Trimethylmorpholine-3-carboxylic acid

Produkt 1

HCID 671669874,6,6-trimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amideAusbeute 61 %

Versuchsvorschrift

The desired compound was prepared according to Method B from 6-chloro-9H-β-carboline-8-ylamine and 4,6,6-trimethyl-morpholine-3-carboxylic acid in 61% yield. 1H-NMR (DMSO-d6, 300 MHz) δ 1.15 (s, 3H), 1.39 (s, 3H), 1.98 (d, 1H), 2.26 (s, 3H), 2.72 (d, 1H), 2.80 (dd, 1H), 3.79(m, 2H), 7.91 (s, 1H), 8.03-8.08 (m, 2H), 8.22 (d, 1H), 8.97 (s, 1H). Retention Time (LC, method: ammonium acetate standard): 1.33 min. MS (M+H+): 373.2.

Aufarbeitung

  1. custom1.33 min

Quellen und Nachweise

ORD-Eintrag
ord-4c25266236574d33b4c75fb2002818ec
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951801B2

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