Thionyl Chloride → 3-Fluoro-2-methylbenzoyl chloride
Reaktionsgleichung
[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:14])=O>>[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([Cl:14])=[O:6]Komponenten
3
Versuchsvorschrift
A solution of 2.87 g of 3-fluoro-2-methylbenzoic acid in 25 ml of thionyl chloride is refluxed for 1.75 hour and the excess thionyl chloride removed under vacuum. To the residue is added toluene (several times) and the toluene removed under vacuum after each addition to give 3-fluoro-2-methylbenzoyl chloride.
Aufarbeitung
- customthe excess thionyl chloride removed under vacuum
- additionTo the residue is added toluene (several times)
- customthe toluene removed under vacuum
- additionafter each addition
Quellen und Nachweise
- ORD-Eintrag
- ord-68580e8b0b3e49b7b5833ece3c1c71da
- Quelldatensatz
- uspto-grants-1997_04
- Patentnummer
- US05624923
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