Ammonia → 4-Bromoisoindolin-1-one

HRID 552391Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 552391
[NH3:1].C[O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[C:6]=1[CH2:12]Br>CO>[Br:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]2[C:6]=1[CH2:12][NH:1][C:4]2=[O:3]

Komponenten

4

Edukt 2

HCID 222Ammonia2×HCID 21907554Methyl 3-bromo-2-(bromomethyl)benzoate

Produkt 1

HCID 219075094-Bromoisoindolin-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

In a 25 mL microwave tube 3-bromo-2-bromomethyl-benzoic acid methyl ester is dissolved in methanol (15 mL) and mixed with 7.0M methanolic ammonia (6.3 mL) and 17.0M aqueous ammonia (7.3 mL). The microwave tube is sealed and the mixture is stirred overnight at room temperature. The precipitate formed is filtered out and washed with cold water, then dried under vacuum to afford the title compound.

Aufarbeitung

  1. customThe microwave tube is sealed
  2. customThe precipitate formed
  3. filtrationis filtered out
  4. washwashed with cold water
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-7fb216503ba340cca3edfc6422d298d0
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951818B2

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