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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 552503Erstellt: 26. Oktober 2026

4-Bromo-2-cyanopyridine → 2'-Cyano-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

https://huagongshe.com/reaction/552503

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt4-Bromo-2-cyanopyridineHCID 693283—
Edukt2-Pyridinecarboxamide, 6-methyl-N-(4-methyl-2-thiazolyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-HCID 49760412—
Produkt2'-Cyano-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (4-methyl-thiazol-2-yl)-amideHCID 24820890—

Reaktionsschritte

The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide in accordance with the general method of example 131, step 2 using 4-Bromo-2-cyanopyridine instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a off-white solid, MS (ISP): m/e=336.3 (M+H)+.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07951824B2
Quelldatensatzuspto-grants-2011_05
ORD IDord-1278ba4a3cb8419a9a477b85ea78ff60
Quellennotizuspto-grants-2011_05