4-Bromo-2-cyanopyridine → 2'-Cyano-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (2-chloro-pyridin-4-yl)-amide

HRID 552511

Reaktionsgleichung

Reaktionsgleichung von HRID 552511
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[C:15](B3OC(C)(C)C(C)(C)O3)[CH:14]=[C:13]([CH3:26])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1.Br[C:28]1[CH:33]=[CH:32][N:31]=[C:30]([C:34]#[N:35])[CH:29]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([C:28]3[CH:33]=[CH:32][N:31]=[C:30]([C:34]#[N:35])[CH:29]=3)[CH:14]=[C:13]([CH3:26])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 6932834-Bromo-2-cyanopyridineHCID 49760409N-(2-Chloropyridin-4-yl)-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamide

Produkt 1

HCID 866145842'-Cyano-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (2-chloro-pyridin-4-yl)-amide

Versuchsvorschrift

The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (2-chloro-pyridin-4-yl)-amide in accordance with the general method of example 131, step 2 using 4-Bromo-2-cyanopyridine instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a white solid, MS (ISP): m/e=350.2, 352.2 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-73a22931574347fe897661164d1a058f
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951824B2

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