2-Chloro-5-fluoro-4-iodopyridine → 2'-Chloro-5'-fluoro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (1-methyl-1h-pyrazol-3-yl)-amide

HRID 552517

Reaktionsgleichung

Reaktionsgleichung von HRID 552517
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[CH:15]=[C:14](B3OC(C)(C)C(C)(C)O3)[CH:13]=[C:12]([CH3:25])[N:11]=2)=[O:9])=[N:3]1.[Cl:26][C:27]1[CH:32]=[C:31](I)[C:30]([F:34])=[CH:29][N:28]=1>>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[CH:15]=[C:14]([C:31]3[C:30]([F:34])=[CH:29][N:28]=[C:27]([Cl:26])[CH:32]=3)[CH:13]=[C:12]([CH3:25])[N:11]=2)=[O:9])=[N:3]1

Komponenten

3

Edukt 2

HCID 248204952-Chloro-5-fluoro-4-iodopyridineHCID 671639792-Methyl-6-((1-methyl-1H-pyrazol-3-yl)carbamoyl)pyridine-4-boronic acid pinacol ester

Produkt 1

HCID 248209602'-Chloro-5'-fluoro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (1-methyl-1h-pyrazol-3-yl)-amide

Versuchsvorschrift

The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide in accordance with the general method of example 131, step 2 using 2-Chloro-5-fluoro-4-iodpyridine instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a white solid, MS (ISP): m/e=346.1, 348.2 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-800675690617458482d18cee0db5b30d
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951824B2

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