2-Amino-6-methylpyridine → 2'-Chloro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide

HRID 552541Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 552541
C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([Cl:18])[CH:13]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[N:22]=1>>[CH3:27][C:23]1[N:22]=[C:21]([NH:20][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([Cl:18])[CH:13]=3)[CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])[CH:26]=[CH:25][CH:24]=1

Komponenten

3

Edukt 2

HCID 157652-Amino-6-methylpyridineHCID 866145902'-Chloro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid ethyl ester

Produkt 1

HCID 866145912'-Chloro-6-methyl-[4,4']bipyridinyl-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide

Versuchsvorschrift

The title compound, was prepared from 2′-Chloro-6-methyl-[4,4′]bipyridinyl-2-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using 2-amino-6methylpyridine instead of 3-chloroaniline to yield the final compound as a white crystalline, MS (ISP): m/e=339.2, 341.1 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-47cdd614c33347c8a6a86985ded37fb5
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951824B2

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