Methyl iodide → 3-{3-[3-(4-Acetyl-3-methoxy-2-propylphenoxy)-propoxy]-2-pyridyl}-propionic acid methyl ester
Reaktionsgleichung
[CH3:1][O:2][C:3](=[O:30])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[O:25])[CH3:24])=[C:19]([OH:26])[C:18]=2[CH2:27][CH2:28][CH3:29])=[CH:10][CH:9]=[CH:8][N:7]=1.[C:31](=O)([O-])[O-].[Cs+].[Cs+].IC>>[CH3:1][O:2][C:3](=[O:30])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[O:25])[CH3:24])=[C:19]([O:26][CH3:31])[C:18]=2[CH2:27][CH2:28][CH3:29])=[CH:10][CH:9]=[CH:8][N:7]=1Komponenten
4
Versuchsvorschrift
Under the conditions of example 2 A, 600 mg of 3-{3-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propoxy]-2-pyridyl}-propionic acid methyl ester in the presence of 940 mg of cesium carbonate instead of potassium carbonate is reacted with 205 mg of iodomethane, worked up, and the crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate. 570 mg of 3-{3-[3-(4-acetyl-3-methoxy-2-propylphenoxy)-propoxy]-2-pyridyl}-propionic acid methyl ester is obtained as oil.
Aufarbeitung
- customthe crude product is chromatographed on silica gel with hexane/0-10% ethyl acetate
Quellen und Nachweise
- ORD-Eintrag
- ord-6418b49c36394e6e902886b5499d3266
- Quelldatensatz
- uspto-grants-1997_04
- Patentnummer
- US05624943
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