Methanol → Methyl 2-(4-bromophenyl)acetate

HRID 55295Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 55295
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12]O>>[CH3:12][O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1

Komponenten

3

Edukt 2

HCID 887MethanolHCID 74654Benzeneacetic acid, 4-bromo-

Produkt 1

HCID 316783Methyl 2-(4-bromophenyl)acetate

Versuchsvorschrift

A solution of 100 g of 4-bromophenylacetic acid in 1.5 l of methanol is mixed with 232 g of Amberlyst 15, and the suspension is stirred for 48 hours at room temperature. The reaction mixture is suctioned off on diatomaceous earth, the filter residue is washed with dichloromethane, and the filtrate is concentrated by evaporation. The residue is taken up in ethyl acetate, washed with 10% sodium bicarbonate solution and saturated common salt solution, dried on sodium sulfate and concentrated by evaporation. 106 g of 4-bromophenylacetic acid methyl ester is obtained as oil.

Aufarbeitung

  1. washthe filter residue is washed with dichloromethane
  2. concentrationthe filtrate is concentrated by evaporation
  3. washwashed with 10% sodium bicarbonate solution and saturated common salt solution
  4. customdried on sodium sulfate
  5. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-685cd69b188c4f41905437882c80882f
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05624943

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