HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 553Erstellt: 23. Oktober 2026
1-Methylpiperazine → 1-(3-bromo-1-methyl-1H-1,2,4-triazol-5-yl)-4-methylpiperazine
https://huagongshe.com/de/reaction/553
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-Methylpiperazine | HCID 53167 | — |
| Edukt | 3,5-Dibromo-1-methyl-1H-1,2,4-triazole | HCID 17186052 | — |
| Reagenz | Sodium t-butoxide | HCID 23676156 | — |
| Katalysator | Binap, (A+-)- | HCID 634876 | — |
| Katalysator | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 1-(3-bromo-1-methyl-1H-1,2,4-triazol-5-yl)-4-methylpiperazine | HCID 125427600 | 0% |
Reaktionsschritte
A mixture of 3,5-dibromo-1-methyl-1H-1,2,4-triazole (142 mg, 0.59 mmol), 1-methylpiperazine (62.0 mg, 0.62 mmol), tris(dibenzylideneacetone)dipalladium(0) (81 mg, 0.09 mmol), BINAP (110 mg, 0.18 mmol) and sodium tert-butoxide (113 mg, 1.18 mmol) in toluene (8 ml) was stirred at 100 °C for 1.5hrs. LCMS indicated no desired product formation. Discarded.
Herkunft & Nachweise
| Quelldatensatz | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-775ba0e2a4c14f008f392711cc2a587a |
|---|
| Quellennotiz | 750 AstraZeneca ELN dataset |
|---|
