2-(N-tert-butylsulfamoyl)-N-phenylacetamide → N-phenyl-2-sulfamoylacetamide

HRID 553467Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 553467
C([NH:5][S:6]([CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:11])(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[S:6]([CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:11])(=[O:7])(=[O:8])[NH2:5]

Komponenten

3

Edukt 1

HCID 579245132-(N-tert-butylsulfamoyl)-N-phenylacetamide

Produkt 1

HCID 21435949N-phenyl-2-sulfamoylacetamideAusbeute 96,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

The solution of compound 2-(N-tert-butylsulfamoyl)-N-phenylacetamide (2.5 g, 9.2 mmol.) in 40 mL of TFA was stirred at room temperature overnight. TLC analysis showed the reaction complete. Excess TFA was removed in vacuo. The value of pH was adjusted to 7-8 with NaHCO3. The mixture was extracted with EtOAc (30 mL×3). The combined organic layer was over Na2SO4, concentrated to afford compound 2-(sulfamoyl)-N-phenylacetamide (1.9 g, 96%), which was used directly without purification.

Aufarbeitung

  1. customthe reaction complete
  2. customExcess TFA was removed in vacuo
  3. extractionThe mixture was extracted with EtOAc (30 mL×3)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-f61b1478c836490cbcaeb3150c00e29a
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048862B2

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