Sodium Carbonate → 2-(2-sulfamoylphenoxy)-N-methylacetamide

HRID 553471

Reaktionsgleichung

Reaktionsgleichung von HRID 553471
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](=[O:11])(=[O:10])[NH2:9].Br[CH2:13][C:14]([NH:16][CH3:17])=[O:15].C(=O)([O-])[O-].[Cs+].[Cs+].C(=O)([O-])[O-].[Na+].[Na+].C(=O)([O-])[O-].[K+].[K+].C(=O)(O)[O-].[Na+].C(=O)(O)[O-].[K+]>>[S:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:1][CH2:13][C:14]([NH:16][CH3:17])=[O:15])(=[O:11])(=[O:10])[NH2:9]

Komponenten

8

Edukt 7

HCID 10340Sodium CarbonateHCID 10796Cesium carbonateHCID 11430Potassium CarbonateHCID 516892Sodium BicarbonateHCID 516893Potassium BicarbonateHCID 6375462-Hydroxybenzene-1-sulfonamideHCID 154907452-Bromo-N-methylacetamide

Produkt 1

HCID 579243292-(2-sulfamoylphenoxy)-N-methylacetamide

Versuchsvorschrift

2-(2-Sulfamoylphenoxy)-N-methylacetamide can be prepared according to the method of Scheme XXXIX. Bromoacetyl bromide can be reacted methylamine hydrochloride in the presence of a base, such as sodium hydroxide to afford 2-bromo-N-methylacetamide. The phenoxy group of 1-(hydroxy)-2-sulfamoylbenzene can be alkylated with 2-bromo-N-methylacetamide in the presence of a base, such as cesium carbonate, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, and the like, to afford 2-(2-sulfamoylphenoxy)-N-methylacetamide.

Quellen und Nachweise

ORD-Eintrag
ord-03d8eda5f97b4236b8da1b60fe3c20b6
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048862B2

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