(4R*,10aS*)-4-(4-fluorophenyl)-1,3,4,7,8,10a-hexahydro-2H-pyrido[1,2-a]azepin-6-one → (4R*,10aR*)-4-(4-fluorophenyl)octahydropyrido[1,2-a]azepin-6-one

HRID 553885Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 553885
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:13]3[C:14](=[O:19])[CH2:15][CH2:16][CH:17]=[CH:18][C@@H:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[H][H]>CO.[Pt]=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]2[N:13]3[C:14](=[O:19])[CH2:15][CH2:16][CH2:17][CH2:18][C@@H:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 69071429(4R*,10aS*)-4-(4-fluorophenyl)-1,3,4,7,8,10a-hexahydro-2H-pyrido[1,2-a]azepin-6-oneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 69073845(4R*,10aR*)-4-(4-fluorophenyl)octahydropyrido[1,2-a]azepin-6-oneAusbeute 95,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Platinum oxide (10 mg) was added to a solution of (4R*,10aS*)-4-(4-fluorophenyl)-1,3,4,7,8,10a-hexahydro-2H-pyrido[1,2-a]azepin-6-one (146 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen stream at room temperature for 25 hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 140 mg of the title compound. The property values of the compound are as follows.

Aufarbeitung

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-efba8e63c9c74867a0ca458b46d27b13
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048878B2

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