Triethyl phosphite → diethyl[(6S*,9aR*)-6-(3-fluorophenyl)-4-oxooctahydroquinolizin-3-yl]phosphonate

HRID 553907Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 553907
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:17][CH2:16][CH2:15][C@@H:14]3[N:9]2[C:10](=[O:19])[CH:11](I)[CH2:12][CH2:13]3)[CH:5]=[CH:6][CH:7]=1.[P:20]([O:27]CC)([O:24][CH2:25][CH3:26])[O:21][CH2:22][CH3:23]>>[F:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[CH2:17][CH2:16][CH2:15][C@H:14]3[N:9]2[C:10](=[O:19])[CH:11]([P:20](=[O:27])([O:24][CH2:25][CH3:26])[O:21][CH2:22][CH3:23])[CH2:12][CH2:13]3)[CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 31215Triethyl phosphiteHCID 69075941(6R*,9aS*)-6-(3-fluorophenyl)-3-iodooctahydroquinolizin-4-one

Produkt 1

HCID 86612701diethyl[(6S*,9aR*)-6-(3-fluorophenyl)-4-oxooctahydroquinolizin-3-yl]phosphonate

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of (6R*,9aS*)-6-(3-fluorophenyl)-3-iodooctahydroquinolizin-4-one (597 mg) with triethyl phosphite (6 mL) was stirred at 120° C. for five hours. The reaction solution was left to cool to room temperature and then concentrated under reduced pressure to obtain 670 mg of the title compound. The property value of the compound is as follows.

Aufarbeitung

  1. waitThe reaction solution was left
  2. temperatureto cool to room temperature
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7f1632ed833e41e788419ba545947c6a
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048878B2

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