(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one → (4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

HRID 553959Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 553959
[F:1][C:2]1[CH:3]=[C:4]([C@@H:10]2[CH2:15][O:14][CH2:13][C@@H:12]3[CH:16]=[CH:17][CH2:18][C:19](=[O:20])[N:11]23)[CH:5]=[C:6]([F:9])[C:7]=1[F:8].[H][H]>CO.[Pt]=O>[F:1][C:2]1[CH:3]=[C:4]([C@@H:10]2[CH2:15][O:14][CH2:13][C@@H:12]3[CH2:16][CH2:17][CH2:18][C:19](=[O:20])[N:11]23)[CH:5]=[C:6]([F:9])[C:7]=1[F:8]

Komponenten

5

Edukt 2

HCID 67464206(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-oneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 44124045(4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-oneAusbeute 100,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Platinum oxide (20.1 mg) was added to a solution of (4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one (250 mg) in methanol (6 mL), and the reaction solution was stirred in a hydrogen atmosphere at room temperature for two hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 252 mg of the title compound. The property value of the compound is as follows.

Aufarbeitung

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f59087ee1c8a48f3b6475732131d0718
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048878B2

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